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Tables 2 and 3 are checklists for the main report and abstract, respectively. Only new and modified items are discussed in this E&E document, as well as six items that retain the CONSORT 2010 [3, 4] wording but require clarification for certain ADs (Box 4). Authors should download and complete Additional file 1 to accompany a manuscript during journal submission.
This study was conducted in accordance with institutional guidelines for the care and use of laboratory animals established by the Animal Ethics Committee of the University of Wageningen, and all animal procedures related to the purpose of the research were approved under the Ethical license of the national competent authority (registration number 2014075.e), securing full compliance the European Directive 2010/63/EU for the use of animals for scientific purposes. The manuscript does not contain clinical studies or patient data. This research was funded by Wageningen University and VLAG Graduate School. Used R scripts are available via -study. M van der Ende, RLC Plas, M van Dijk, JT Dwarkasing, F van Gemerden, A Sarokhani, HJM Swarts, EM van Schothorst, S Grefte, RF Witkamp and K van Norren give their consent for publication and declare that they have no conflict of interest.
All search results from the databases were imported to the web-based bibliographic management software, RefWorks 2017 by ProQuest. After exclusion of duplicates and records before 01.01.2010, two reviewers independently screened titles and abstracts of the remaining articles for relevance in relation to the research question and the inclusion and exclusion criteria. Afterwards, all full-text articles were further checked for relevance by two independent reviewers. Any inconsistencies between the two reviewers regarding study selection for final inclusion were resolved by discussion with a third reviewer.
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